View abstract. View abstract. Jarvis S, Li C, Bogle RG. Journal of Animal Physiology & Animal Nutrition 2008;92(2):221-222. Mirmiran, P., Fazeli, M. R., Asghari, G., Shafiee, A., and Azizi, F. Effect of pomegranate seed oil on hyperlipidaemic subjects: a double-blind placebo-controlled clinical trial. 2011;77(9):3061-3067. Effects of consumption of pomegranate juice on carotid intima-media thickness in men and women at moderate risk for coronary heart disease. Food Chem.Toxicol 2010;48(4):1045-1051. McCarrell, E. M., Gould, S. W., Fielder, M. D., Kelly, A. F., El, Sankary W., and Naughton, D. P. Antimicrobial activities of pomegranate rind extracts: enhancement by addition of metal salts and vitamin C. BMC.Complement Altern.Med. Effects of Quercus ilex L. and Punica granatum L. polyphenols against ethanol-induced gastric damage in rats. Balbir-Gurman A, Fuhrman B, Braun-Moscovici Y, et al. Phytother.Res. 2011;49(7):1511-1520.
Alimentos e Nutrio 2010;21(4):509-517. Xu, K. Z., Zhu, C., Kim, M. S., Yamahara, J., and Li, Y. Pomegranate flower ameliorates fatty liver in an animal model of type 2 diabetes and obesity. 9-23-2009;57(18):8344-8349. View abstract. 2000;71(5):1062-1076. Select a condition to view a list of vitamins. 2010;40(1):229-244. Part 182 -- Substances Generally Recognized As Safe. A randomized phase II study of pomegranate extract for men with rising PSA following initial therapy for localized prostate cancer. View abstract. View abstract. Use of Punica granatum as an antifungal agent against candidosis associated with denture stomatitis. Chong, M. F., Macdonald, R., and Lovegrove, J. Indian J.Pharm.Sci. J Agric Food Chem 2000;48:4581-9. Su, X., Sangster, M. Y., and D'Souza, D. H. In vitro effects of pomegranate juice and pomegranate polyphenols on foodborne viral surrogates. Turk G, Sonmez M, Aydin M, Yuce A, Gur S, Yuksel M, Aksu EH, and Aksoy H. Effects of pomegranate juice consumption on sperm quality, spermatogenic cell density, antioxidant activity and testosterone level in male rats. 2010;24 Suppl 2:S196-S203. View abstract. J Int Acad Periodontol 2003;5:106-15. Haidari M, Ali M, Ward Casscells S 3rd, Madjid M. Pomegranate (Punica granatum) purified polyphenol extract inhibits influenza virus and has a synergistic effect with oseltamivir. Adhikari, A., Devkota, H. P., Takano, A., Masuda, K., Nakane, T., Basnet, P., and Skalko-Basnet, N. Screening of Nepalese crude drugs traditionally used to treat hyperpigmentation: in vitro tyrosinase inhibition.
USDA Web site. 2008;30(3):183-193. Int J Impot.Res 2007;19(6):564-567. Faria, A., Monteiro, R., Azevedo, I., and Calhau, C. Comment on safety and antioxidant activity of a pomegranate ellagitannin-enriched polyphenol dietary supplement in overweight individuals with increased waist size. Beneficial effects of pomegranate juice on oxidation-sensitive genes and endothelial nitric oxide synthase activity at sites of perturbed shear stress. Rock, W., Rosenblat, M., Miller-Lotan, R., Levy, A. P., Elias, M., and Aviram, M. Consumption of wonderful variety pomegranate juice and extract by diabetic patients increases paraoxonase 1 association with high-density lipoprotein and stimulates its catalytic activities. Atherosclerosis 2001;158:195-8. Radjabian, T. Husseini H. F. Karami M. Rasooli I. and Faghihzadeh S. Effect of pomegranate fruit juice and seed oil on serum lipid levels and atherosclerosis development in hypercholesterolemic rabbits. Aviram M, Dornfeld L. Pomegranate juice consumption inhibits serum angiotensin converting enzyme activity and reduces systolic blood pressure. J Sci Food Agric. View abstract. Murthy KN, Reddy VK, Veigas JM, Murthy UD. Ignarro, L. J., Byrns, R. E., Sumi, D., de Nigris, F., and Napoli, C. Pomegranate juice protects nitric oxide against oxidative destruction and enhances the biological actions of nitric oxide. Basic report: 09286, pomegranates, raw. Clin.Nutr. 2009;47(6):1221-1230. View abstract. Farkas D, Oleson LE, Zhao Y, et al. Indian J.Dent.Res. View abstract. View abstract. Food Chem.Toxicol. Menopause 2012;19(4):426-32. View abstract. Electronic Code of Federal Regulations. J.Strength.Cond.Res.
Phytother.Res. Pomegranate juice does not affect the disposition of simvastatin in healthy subjects. J Agric Food Chem 2007;55:10050-4. 11-25-2009;57(22):10636-10644. Heber D, Seeram NP, Wyatt H, et al. View abstract. Afaq, F., Khan, N., Syed, D. N., and Mukhtar, H. Oral feeding of pomegranate fruit extract inhibits early biomarkers of UVB radiation-induced carcinogenesis in SKH-1 hairless mouse epidermis. Kuang, N. Z., He, Y., Xu, Z. Progress in Modern Biomedicine 2008;8(11):2107-2108, 2125. 
J.Ethnopharmacol. Braz J Med Biol Res 2000;33:1351-5. Evidence of anti-obesity effects of the pomegranate leaf extract in high-fat diet induced obese mice. View abstract. Pai, M. B., Prashant, G. M., Murlikrishna, K. S., Shivakumar, K. M., and Chandu, G. N. Antifungal efficacy of Punica granatum, Acacia nilotica, Cuminum cyminum and Foeniculum vulgare on Candida albicans: an in vitro study. The endotoxemia marker lipopolysaccharide-binding protein is reduced in overweight-obese subjects consuming pomegranate extract by modulating the gut microbiota: A randomized clinical trial. J.Agric.Food Chem. Drinking pomegranate juice might decrease how fast the body breaks down carbamazepine (Tegretol). 1995;20(9):556-8, 576, inside. Taking pomegranate along with some medications that are changed by the body might increase the effects and side effects of your medication. Cancer Prev.Res. J.Agric.Food Chem. View abstract. Allergy 1999;54:287-8. Int J Sport Nutr Exerc Metab. Acta Horticulturae 2008;765:31-34. J.Aquat.Anim Health 2010;22(1):14-20.
Qu, W. Pan Z. L. and Ma H. Extraction modeling and activities of antioxidants from pomegranate marc. Stowe, C. B. Kaplan M, Hayek T, Raz A, et al. View abstract. Influence of fruit juices on drug disposition: discrepancies between in vitro and clinical studies. View abstract. View abstract. View abstract. Integr.Cancer Ther. Curr Urol Rep 2006;7:7. Vroegrijk, I. O., van Diepen, J. J Ethnopharmacol. Taking pomegranate doesn't seem to lower cholesterol in people with or without high cholesterol. A randomized, double-blind, placebo-controlled study of the effects of pomegranate extract on rising PSA levels in men following primary therapy for prostate cancer. A. J.Med.Food 2011;14(7-8):695-701. 2016 Oct 15;23(11):1103-12.View abstract. Xie, Y., Morikawa, T., Ninomiya, K., Imura, K., Muraoka, O., Yuan, D., and Yoshikawa, M. Medicinal flowers. Effect of pomegranate juice consumption on blood pressure in type 2 diabetic patients. Saruwatari, A., Okamura, S., Nakajima, Y., Narukawa, Y., Takeda, T., and Tamura, H. Pomegranate juice inhibits sulfoconjugation in Caco-2 human colon carcinoma cells. Safety and antioxidant activity of pomegranate ellagitannin-enriched polyphenol dietary supplement in overweight individuals with increased waist size. View abstract. Khan, G. N., Gorin, M. A., Rosenthal, D., Pan, Q., Bao, L. W., Wu, Z. F., Newman, R. A., Pawlus, A. D., Yang, P., Lansky, E. P., and Merajver, S. D. Pomegranate fruit extract impairs invasion and motility in human breast cancer. Atherosclerosis 2006;188(1):68-76. Some early research shows that drinking pomegranate juice might improve blood flow to the heart. 2011;16(3):245-253. View abstract. International Journal of Fruit Science 2009;9(3):226-231. View abstract. View abstract. International multidimensional authenticity specification (IMAS) algorithm for detection of commercial pomegranate juice adulteration. Nitric.Oxide. Zhang L., Fu Q. and Zhang Y. View abstract. Composition of anthocyanins in pomegranate flowers and their antioxidant activity. View abstract. 
Gil MI, Tomas-Barberan FA, Hess-Pierce B, et al.
Hajimahmoodi, M. Oveisi M. R. Sadeghi N. Jannat B. and Nateghi M. Antioxidant capacity of plasma after pomegranate intake in human volunteers. Food Chem.Toxicol. J.Pharm.Pharmacol. Emerg Med J 2010;27:74-5. WebMD does not provide medical advice, diagnosis or treatment. 2010;24(4):1087-1091. Wound healing activity of Malva sylvestris and Punica granatum in alloxan-induced diabetic rats. 2021;28(3):226-233. Nutr.Res. View abstract. Hanif, S., Shamim, U., Ullah, M. F., Azmi, A. S., Bhat, S. H., and Hadi, S. M. The anthocyanidin delphinidin mobilizes endogenous copper ions from human lymphocytes leading to oxidative degradation of cellular DNA. Hossin, F. L. A. Antiviral Res. J.Clin.Biochem.Nutr.
View abstract. Zhongguo Zhong.Yao Za Zhi. Shukla, M., Gupta, K., Rasheed, Z., Khan, K. A., and Haqqi, T. M. Bioavailable constituents/metabolites of pomegranate (Punica granatum L) preferentially inhibit COX2 activity ex vivo and IL-1beta-induced PGE2 production in human chondrocytes in vitro. View abstract. Neurobiol.Dis 2006;24(3):506-515. Devatkal, S. K., Narsaiah, K., and Borah, A. Anti-oxidant effect of extracts of kinnow rind, pomegranate rind and seed powders in cooked goat meat patties. / Compostos fenlicos da polpa e sementes de rom (Punica granatum, L.): atividade antioxidante e protetora em clulas MDCK. Most research shows that taking pomegranate products doesn't help with weight loss. Kim, Y. H. and Choi, E. M. Stimulation of osteoblastic differentiation and inhibition of interleukin-6 and nitric oxide in MC3T3-E1 cells by pomegranate ethanol extract. View abstract. Aviram, M., Dornfeld, L., Kaplan, M., Coleman, R., Gaitini, D., Nitecki, S., Hofman, A., Rosenblat, M., Volkova, N., Presser, D., Attias, J., Hayek, T., and Fuhrman, B. Pomegranate juice flavonoids inhibit low-density lipoprotein oxidation and cardiovascular diseases: studies in atherosclerotic mice and in humans. 2008;46(12):811-816. View abstract. View abstract. J.Egypt.Soc.Parasitol. Journal of the American Oil Chemists' Society 2009;86(10):1029. Acta Medica Iranica 2009;47(2):125-132. 9-24-2008;56(18):8704-8713. View abstract. The Herbal Alternatives for Menopause (HALT) Study: background and study design. Food Chem.Toxicol. Appl.Environ.Microbiol. Braga LC, Shupp JW, Cummings C, et al. J.Agric.Food Chem. View abstract. View abstract. View abstract. View abstract. View abstract. 4-7-2009;7(7):1445-1453.
CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects.
Int J Vitam.Nutr Res 2006;76(3):147-151.
View abstract.
View abstract. Leiva, K. P., Rubio, J., Peralta, F., and Gonzales, G. F. Effect of Punica granatum (pomegranate) on sperm production in male rats treated with lead acetate. Gasmi, J. and Sanderson, J. T. Growth Inhibitory, Antiandrogenic, and Pro-apoptotic Effects of Punicic Acid in LNCaP Human Prostate Cancer Cells. Drinking pomegranate juice might decrease how fast the body breaks down warfarin (Coumadin). Chemopreventive and adjuvant therapeutic potential of pomegranate (Punica granatum) for human breast cancer. View abstract. 2-Methyl-pyran-4-one-3-O-beta-D-glucopyranoside isolated from leaves of Punica granatum inhibits the TNFalpha-induced cell adhesion molecules expression by blocking nuclear transcription factor-kappaB (NF-kappaB). Hidaka M, Okumura M, Fujita K, et al. Food Chemistry 2011;127(4):1444-1449. View abstract. Phytother Res. Modern Food Science and Technology 2008;24(1):23-27. Gheflati A, Mohammadi M, Ramezani-Jolfaie N, Heidari Z, Salehi-Abargouei A, Nadjarzadeh A. Borochov-Neori, H., Judeinstein, S., Harari, M., Bar-Ya'akov, I., Patil, B. S., Lurie, S., and Holland, D. Climate effects on anthocyanin accumulation and composition in the pomegranate (Punica granatum L.) fruit arils. Zhongguo Zhong.Yao Za Zhi. Some medications are changed and broken down by the body. View abstract.
J Med Food 2004;7:305-8. J.Agric.Food Chem. 2010;24(2):182-185. Int.J.Oncol. View abstract. Komperda KE. Menezes, S. M., Cordeiro, L. N., and Viana, G. S. Punica granatum (pomegranate) extract is active against dental plaque. View abstract. World Journal of Agricultural Sciences 2010;6(4):338-344. Elfalleh, W., Nasri, N., Marzougui, N., Thabti, I., M'rabet, A., Yahya, Y., Lachiheb, B., Guasmi, F., and Ferchichi, A. Physico-chemical properties and DPPH-ABTS scavenging activity of some local pomegranate (Punica granatum) ecotypes. Hayouni, E. A., Miled, K., Boubaker, S., Bellasfar, Z., Abedrabba, M., Iwaski, H., Oku, H., Matsui, T., Limam, F., and Hamdi, M. Hydroalcoholic extract based-ointment from Punica granatum L. peels with enhanced in vivo healing potential on dermal wounds. Wang RF, Xie WD, Zhang Z, et al. View abstract. View abstract. Zhu, J. Yu L. Zhang L. Cui X. Ai H. Effect of water extraction from pomegranate peel on cardiac electrical activity of Bufo Bufo Gargarizans in vivo. Seeram, N. P., Zhang, Y., McKeever, R., Henning, S. M., Lee, R. P., Suchard, M. A., Li, Z., Chen, S., Thames, G., Zerlin, A., Nguyen, M., Wang, D., Dreher, M., and Heber, D. Pomegranate juice and extracts provide similar levels of plasma and urinary ellagitannin metabolites in human subjects.
View abstract. Chem.Pharm.Bull. XXIII. Kelebek, H. and Canbas A. Organic acid, sugar and phenolic compounds and antioxidant capacity of Hicaz pomegranate juice. View abstract. Nutrients. Sayyari, M., Valero, D., Babalar, M., Kalantari, S., Zapata, P. J., and Serrano, M. Prestorage oxalic acid treatment maintained visual quality, bioactive compounds, and antioxidant potential of pomegranate after long-term storage at 2 degrees C. J.Agric.Food Chem. Jardini, F. A. Lima A. de Mendona R. M. Z. Pinto R. J. Mancini D. A. P. and Mancini Filho J. Phenolic compounds from pulp and seeds of pomegranate (Punica granatum, L.): antioxidant activity and protection of MDCK cells.
View abstract. J AOAC Int 1996;79(5):1124-9. View abstract. Kasimsetty, S. G., Bialonska, D., Reddy, M. K., Thornton, C., Willett, K. L., and Ferreira, D. Effects of pomegranate chemical constituents/intestinal microbial metabolites on CYP1B1 in 22Rv1 prostate cancer cells. Neurath AR, Strick N, Li YY, Debnath AK. Diabetes. Rasheed, Z., Akhtar, N., and Haqqi, T. M. Pomegranate extract inhibits the interleukin-1beta-induced activation of MKK-3, p38alpha-MAPK and transcription factor RUNX-2 in human osteoarthritis chondrocytes. 6-9-2010;58(11):6804-6808. Journal of Pharmacy Research 2010;3(12):2850-2852. 2-1-2008;11(3):351-358. Pharmacol Res. View abstract. J Chromatogr 1988;438:438-42. Potential interaction between pomegranate juice and warfarin. peel. Photochem Photobiol 2005;81(1):38-45. Accessed June 1, 2016. Jurenka, J. S. Therapeutic applications of pomegranate (Punica granatum L.): a review. Drugs Exp.Clin.Res. View abstract. This might increase the effects and side effects of tolbutamide (Orinase). The effects of pomegranate juice consumption on blood pressure and cardiovascular health. Before taking pomegranate, talk to your healthcare provider if you take any medications that are changed by the body. J Ethnopharmacol 2005;99:239-44. Arthritis Res.Ther. View abstract. Rosuvastatin (Crestor) is broken down by the body in the liver. [Identification of the root of Punica granatum in galenic preparations using TLC].
2009;14(5):1808-1817. View abstract. Ajaikumar KB, Asheef M, Babu BH, Padikkala J. Mol Nutr Food Res. Concentrated pomegranate juice improves lipid profiles in diabetic patients with hyperlipidemia. Some medications are changed and broken down by the body. Food and Drug 2009;11(9):22-25. Various parts of the tree and fruit are used to make medicine. Bialonska, D., Kasimsetty, S. G., Khan, S. I., and Ferreira, D. Urolithins, intestinal microbial metabolites of Pomegranate ellagitannins, exhibit potent antioxidant activity in a cell-based assay. 7-8-2011;410(3):581-586. Proceedings of the 11th Biennial Meeting of the Society for Free Radical Research International, 2002 Feb:1-9. BMJ 2000;321:1153-4. 2010;19(8):e182-e190. View abstract. McFarlin, B. K., Strohacker, K. A., and Kueht, M. L. Pomegranate seed oil consumption during a period of high-fat feeding reduces weight gain and reduces type 2 diabetes risk in CD-1 mice. Scientia Agricultura Sinica 2009;42(11):4035-4041.
Weisburg, J. H., Schuck, A. G., Silverman, M. S., Ovits-Levy, C. G., Solodokin, L. J., Zuckerbraun, H. L., and Babich, H. Pomegranate extract, a prooxidant with antiproliferative and proapoptotic activities preferentially towards carcinoma cells. Indian J.Exp.Biol. B., and Kim, S. Y. Pharmacotherapy 2009;29:1002-6. Australian Journal of Basic and Applied Sciences 2009;3(4):4634-4643. Wongwattanasathien, O., Kangsadalampai, K., and Tongyonk, L. Antimutagenicity of some flowers grown in Thailand. Pantuck AJ, Pettaway CA, Dreicer R, et al. 10-14-2009;57(19):9197-9209. Maternal dietary supplementation with pomegranate juice is neuroprotective in an animal model of neonatal hypoxic-ischemic brain injury. 2010;67(5):511-516. El, Kar C., Ferchichi, A., Attia, F., and Bouajila, J. Pomegranate (Punica granatum) juices: chemical composition, micronutrient cations, and antioxidant capacity. 2010;21(3):334-336. 2009;47(1):50-54. McDougall, G. J., Ross, H. A., Ikeji, M., and Stewart, D. Berry extracts exert different antiproliferative effects against cervical and colon cancer cells grown in vitro. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182. Adams, L. S., Seeram, N. P., Aggarwal, B. Sahebkar A, Simental-Mendia LE, Giorgini P, Ferri C, Grassi D. Lipid profile changes after pomegranate consumption: a systematic review and meta-analysis of randomized controlled trials. Ren Fail. Iranian Journal of Endocrinology and Metabolism 2008;9:399-405, 470. Allergy to pomegranate (Punica granatum). 2011;91(12):2160-2165. Indian J.Biochem.Biophys. 2009;71(2):136-139. Pharmacogn.Mag. View abstract. 2009;72(12):2508-2516. Alighourchi, H. Barzegar M. and Abbasi S. Effect of gamma irradiation on the stability of anthocyanins and shelf-life of various pomegranate juices. 
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